in vivo ketogenesis via GLUCAGON

"Every Day And In Every Way I Am Getting Better And Better" ...
.
.
.
Regulation of in vivo ketogenesis: role of free fa...[Diabetes Metab. 1996]

Diabetes Metab. 1996 Oct;22(5):299-304.Links

Regulation of in vivo ketogenesis: role of free fatty acids and control by epinephrine, thyroid hormones, insulin and GLUCAGON.

Beylot M.

Laboratoire de Physiopathologie Métabolique et Rénale, Faculté de Médecine Alexis Carre, Lyon, France.

The production of ketone bodies (KB) is dependent on the amount of free fatty acids (FFA) supplied to the liver and on the hepatic metabolic fate of fatty acids and their orientation towards oxidation and ketogenesis or reesterification.

In vivo ketogenesis can thus be regulated at the pre-hepatic (lipolysis) or hepatic level. We first investigated the role of FFA availability on the rate of KB production and then the effects of epinephrine, thyroid hormones, insulin and glucagon on the relationship between FFA availability and KB production.

An increase in FFA availability augmented KB production not only by a mass effect but also by a diversion of hepatic fatty acid metabolism towards ketogenesis.

The ketogenic effect of epinephrine and thyroid hormones depended only on their stimulatory action on lipolysis and FFA availability.

An excess of thyroid hormones had no direct effect on hepatic ketogenesis, whereas the direct action of epinephrine on liver was rather anti-ketogenic.

Glucagon stimulated hepatic ketogenesis, whereas a short-term increase in insulinemia [EG via Transient Supernormal Glycemia ("TSG")] within the physiological range appeared to have no restrictive action.

PMID: 8896990

Related Articles

• Human ketone body production and utilization studied using tracer techniques: regulation by free fatty acids, insulin, catecholamines, and thyroid hormones. [Diabetes Metab Rev. 1989]
• 
  
• Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise. [J Clin Invest. 1984]
• 
  
• Effects of free fatty acids, insulin, glucagon and adrenaline on ketone body production in humans. [Ciba Found Symp. 1982]
• 
  
• Hormonal regulation of ketone-body metabolism in man. [Biochem Soc Symp. 1978]
• 
  
• Effects of free fatty acid availability, glucagon excess, and insulin deficiency on ketone body production in postabsorptive man. [J Clin Invest. 1983]
• » See all Related Articles...

Patient Drug Information

• Thyroid (Armour® Thyroid) Thyroid is a hormone produced by the body. When taken correctly, thyroid is used to treat the symptoms of hypothyroidism (a condition where the thyroid gland does not produce enough thyroid hormone). Symptoms of hypothyr...
  » read more ...
• 
  
• Glucagon (GlucaGen Diagnostic Kit®) Glucagon is a hormone produced in the pancreas. Glucagon is used to raise very low blood sugar. Glucagon is also used in diagnostic testing of the stomach and other digestive organs.
• 
  
  » read more ...
• 
  

eat one meal at night avoid toxins exercise properly

"Every Day And In Every Way I Am Getting Better And Better" ...
.
.
.
Tina Marie Welcomes World-Renowned Author and Talk Show Host Ori Hofmekler on Her Weekly 'Holistic Living' Talk Show on the Voice America Network

Phoenix, AZ June, 2008 -- Internet broadcasting pioneer, producing and syndicating online audio and video, today announced that the world renowned author of "The Warrior Diet", Ori Hofmekler will join Tina Marie on her Holistic Living radio show on the VoiceAmerica, online internet talk radio network, on June 17th, 2008.

Ori Hofmekler will share “The Warrior Diet” ; a call for action. Based on survival science and anthropological research, the book proposes a radical yet surprisingly effective solution to weight gain, obesity, diabetes and their related diseases. Its premise: eat one main meal at night, avoid chemicals, exercise properly. On the show, Ori will share his innate knowledge on how to nourish the body in sync with its innate circadian clock – separating between a.m. foods to p.m. foods for effective removal of toxins, increased breakdown of fat for energy, increased utilization of nutrients and improved resilience to stress. The result – a leaner, stronger and healthier body.

National speaker, author and Holistic Nutritional Consultant, Tina Marie Jones, will have Ori Hofmekler show how recent studies on intermittent fasting have shown the benefits of following eating programs similar to The Warrior Diet. "Mice and rats maintained on an intermittent fasting regiment lived up to 30% longer than those fed ad libitum." and why such meal skipping diets have been shown to improve glucose regulation, reduce blood pressure and enhance cardiovascular stress adaptation, improve renal function during aging, and increase the resistance of animals to disease in experimental models of cancer and neurodegenerative disorders.

Ori Hofmekler is a modern renaissance man whose formative military experience prompted a life interest in survival science. He graduated the Bezalel Academy of Art in Jerusalem and received a degree in Human Sciences by the Hebrew University. A world renowned artist, Ori’s work has been featured in magazines worldwide and artbooks of his political satire works were published in the U.S. and Europe. As editor and chief of Mind and Muscle Power magazine, Ori introduced his diet approach to the public to immediate acclaim from readers and professionals. The Warrior Diet book was published in 2002 in the U.S., France and Italy and has been featured in newspapers, magazines and science journals. Its new revised edition was published in 2007. In 2003, Hofmekler authored the highly acclaimed Maximum Muscle Minimum Fat book, addressing the secret science behind muscle gain and fat loss. In 2006, he authored The Anti-Estrogenic Diet, dedicated to providing solutions against health shattering chemicals in the environment, food and water. In 2008 he revised Maximum Muscle Minimum Fat to a new expanded edition. Ori’s “Take No Prisoners” newsletter exposes fallacies and dirty little secrets in the areas of diet and fitness and present the true facts regarding human survival in today’s world. Available at www.WarriorDiet.com and www.DefenseNutrition.com.

"Holistic Living with Tina Marie" airs live on Tuesdays at 10 a.m. Pacific / 12 p.m. Central / 1 p.m. Eastern on The VoiceAmerica Health & Wellness Channel. To access the show, log on at http://www.modavox.com/voiceamericahealth. All shows will be available in Tina Marie's Content Library on The VoiceAmericaTM Health & Wellness Channel for on-demand and pod cast download.

The VoiceAmericaTM Network offers the latest conversations in a talk radio format, providing education, interaction, and advice on key issues live, on demand as well as through pod cast download. If interested in hosting a talk radio show on VoiceAmerica Network, or advertising/sponosorship information and other show details contact Melissa Schmitz, Health & Wellness Channel Director at 480-294-6410 or at melissa.schmitz@modavox.com.

ABOUT Tina Marie Jones: Always impassioned by health, healing and the spiritual connection to the human body, Tina Marie brings a culmination of all the teachings she has pursued over the years. From her degrees in Holistic Nutrition to her training in Spiritual Healing and Personal Counseling, she takes time to listen and connect with each client in a sacred and supportive manner. Like the gentle flow of a mountain stream, she balances her evolving career with her responsibilities as a mother & wife, PhD student, church volunteer, along with various other activities she chooses to participate in. Tina Marie is a true model of following your heart, living in balance and being in connection with the divine powers that guide our days. Tina Marie is a nutritional consultant who sees clients in her clinic and in remote offices such as Starbucks -- always a nice format to identify the unhealthy American diet. She keeps herself fit, educated and available to her family and clients. Despite the sense of humor, Tina Marie takes what she does very seriously. "We are in a war for our health", she quotes and is ready to be on the battleground for all her clients. The founder and President of Optimal Health Corporation, Optimal Health Consulting, and Optimal Health Education, Mrs. Jones is committed to the serving the health and understanding her clients through education, hands on experiential lessons, and one-on-one support.

ABOUT VoiceAmerica / Modavox: (OTC.BB MDVX), Modavox is the leading producer and distributor of online talk radio content, streaming approximately 250 hours of live programs and scheduled replays weekly on its Modavox VoiceAmerica™ Network (http://www.voiceamerica.com). Modavox, Inc. (http://www.modavox.com) is a pioneer in internet broadcasting, producing and syndicating online audio and video, and offering innovative, effective and comprehensive online tools for reaching targeted niche communities worldwide. Through its patented Modavox Central™ technology, Modavox "takes the search out of search," delivering content straight to desktops and internet-enabled devices. Through its proprietary StreamSafe™, WebcastWizard™ and Stream Syndicate™ tools, Modavox provides managed access for live and on-demand internet broadcasting and syndication, content management, online meetings, event management, enterprise communications and distance learning.

Forward-Looking Statements: This release contains "forward-looking statements" for purposes of the Securities and Exchange Commission's "safe harbor" provisions under the Private Securities Litigation Reform Act of 1995 and Rule 3b-6 under the Securities Exchange Act of 1934. These forward-looking statements are subject to various risks and uncertainties that could cause Modavox's actual results to differ materially from those currently anticipated, including the risk factors identified in Modavox's filings with the Securities and Exchange Commission.

Website Link: http://www.voiceamerica.com

Contact Info:

Melissa Schmitz
2617 S. 46th St., Suite 300, Phoenix, AZ 85034
Phone: 480-294-6410
Website: http://www.voiceamerica.com