PROinsulin Cpeptide kidney healing effects aka C-Peptide effects on renal physiology and diabetes

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C-Peptide effects on renal physiology and diabetes. [Exp Diabetes Res. 2008] - PubMed Result

Exp Diabetes Res. 2008;2008:281536. Links

PROinsulin Cpeptide kidney healing effects ...

Rebsomen L, Khammar A, Raccah D, Tsimaratos M.

UPRES EA 21-93, Laboratoire de Diabétologie, Faculté de Médecine de Marseille, Université de la Méditerranée, 13385 Marseille Cedex 05, France.

The C-peptide of proinsulin is important for the biosynthesis of insulin and has for a long time been considered to be biologically inert. Animal studies have shown that some of the renal effects of the C-peptide may in part be explained by its ability to stimulate the Na,K-ATPase activity. Precisely, the C-peptide reduces diabetes-induced glomerular hyperfiltration both in animals and humans, therefore, resulting in regression of fibrosis. The tubular function is also concerned as diabetic animals supplemented with C-peptide exhibit better renal function resulting in reduced urinary sodium waste and protein excretion together with the reduction of the diabetes-induced glomerular hyperfiltration. The tubular effectors of C-peptide were considered to be tubule transporters, but recent studies have shown that biochemical pathways involving cellular kinases and inflammatory pathways may also be important. The matter theory concerning the C-peptide effects is a metabolic one involving the effects of the C-peptide on lipidic metabolic status.This review concentrates on the most convincing data which indicate that the C-peptide is a biologically active hormone for renal physiology.

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